Fig. 2.

E2-induced islet insulin synthesis is mediated through ERα in vivo. Preproinsulin expression (A) and pancreas insulin concentration (B) after treatment with E2 (4 μg/d) for 4 d in female ERαlox/lox and PERαKO^−/− mice (n = 10–14/group). V, vehicle. Results are expressed as mean ± SEM. *P < 0.05; **P < 0.01.