Skip to main content
. 2010 Jun 29;107(29):13057–13062. doi: 10.1073/pnas.0914501107

Fig. 4.

Fig. 4.

E2-induced insulin synthesis involves extranuclear localization of ERα. (A) MIN6 cells were transfected with an ERE reporter construct (ERE-Luc). Relative luciferase activity was measured after treatment with E2 (10−8 M), PPT (10−8 M), estren (10−8 M), and EDC (10−8 M) for 48 h. (B and C) Effects of estren (10−8 M) and EDC (10−8 M) treatment on preproinsulin expression (B) and insulin concentration (C) WT mouse islets. V, vehicle. Results are reported as mean ± SEM. *P < 0.05; **P < 0.01.