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. 2010 Jun 29;107(29):13063–13068. doi: 10.1073/pnas.1002372107

Fig. 6.

Fig. 6.

CCR1 antagonist BL5923 blocks expansion of metastatic lesions and prolongs host survival. (A) Liver metastasis foci from mice treated with vehicle or BL5923 (50 mg/kg). Mice were injected with CMT93 cells (Left) or HT29 cells (Right). (Scale bars, 100 μm.) (B) Quantification of metastatic lesions in mice injected with CMT93 cells, and treated with the vehicle or BL5923 at 20 or 50 mg/kg (BL: 25 or BL: 50, respectively). Each circle represents an individual mouse. Horizontal lines show the means of the respective groups. *P < 0.01 compared with Vehicle (n = 11–17 mice in each group). (C) Quantification of the metastatic lesions in mice treated with vehicle (V) or 50 mg/kg of BL5923 (BL). Mice were injected with HT29 (Left) or HCT116 (Right) cells. Each circle represents an individual mouse. Horizontal lines show the means of the respective groups. *P < 0.04 compared with vehicle (n = 6–7 mice in each group). (D and E) Kaplan-Meier plots showing survivals of the host mice treated with the vehicle or BL5923 (BL: 50 mg/kg). Mice were injected with CMT93 (D) or HT29 (E). *P = 0.004 compared with vehicle (n = 7–11 mice in each group).