Table 1.
Summary of published cases of erlotinib-induced acute liver toxicity
| Diagnosis | Age/ sex | Dose of erlotinib mg | Concomitant drug | Known liver function abnormality | Time to first elevation LFT | Outcome Time to recover LFT | |
|---|---|---|---|---|---|---|---|
| Liu et al., 2007 [7] | lung cancer | 67/F | 150 | none | none | day 14 | fatal |
| 100 by reinductior | day 10 after reinduction | ||||||
| Ramanarayanan and Scarpace, 2007 [5] | pancreatic cancer | 70/M | 100 | gemcitabine | none | day 14 | recovered 6 weeks |
| Saif, 2008 [6] | pancreatic cancer | 52/M | 100 | gemcitabine | none | week 7 | recovered 8 weeks |
| Pellegrinotti et al., 2009 [8] | lung cancer | 77/M | 100 | oral antidiabetic | none | day 12 | fatal |
| omeprazole | |||||||
| prednisone | |||||||
| furosemide | |||||||
| Present case | lung cancer | 53/M | 150 | phenprocoumon | liver metastasis | day 10 | fatal |
LFT = Liver function tests.