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. 2010 Jul 13;103(3):332–339. doi: 10.1038/sj.bjc.6605767

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Copyright © 2010 Cancer Research UK

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Pharmacokinetics of figitumumab and docetaxel. (A) Mean (±s.d.) plasma concentration–time profiles of figitumumab in cycles 1 and 4 when given in combination with docetaxel. (B) Dose-normalised docetaxel concentration–time profile in cycles 1 and 4. (C) Dose-normalised C_max in the absence and presence of figitumumab. (D) Dose-normalised AUC_last in the absence and presence of figitumumab (open circles indicate individual observations; short line indicates mean values; and dashed line joins observations in cycles 1 and 4 from the same patients). Abbreviations: −figitumumab, without figitumumab; +figitumumab, with figitumumab.