Table 4. Pharmacokinetic parameters (mean±s.d.) of figitumumab given in combination with docetaxel.

	Cycle 1			Cycle 4
Dose (mg kg–1)	n	C1 h (mg l–1)	AUC0–day22 (mg h l–1)	n	C1 h (mg l–1)	Cday22 (mg l–1)	AUC0–day22 (mg h l–1)	Accumulation ratio
0.1	3	1.34±0.36	—	2	1.04, 1.54	—	—	—
0.4	3	7.42±0.82	1010±164	3	6.9±1.75	—	774±40	0.78±0.16
0.8	3	17.9±6.8	2050±649	3	17.8±2.1	0.288a	2290±82	1.1±0.3
1.5	3	32.3±4.2	5110±2640	1	54.6	12.4	1260	1.5
3	3	57.7±23.7	10 500±3750	2	75.5, 126	31.4, 33.1	25 500, 24 600	2.2, 1.8
6	3	129±24	26 700±2770	2	203, 172	57.1, 37.2	46 400, 40 900	1.7, 1.4
10	9	211±33b	38 200±8000	7	324±48c	57.6, 101d	72 400±18 900	1.8±0.4
20	6	407±160e	82 100±23 500	5	658±185	199±73f	158 000±64 300	2.0±0.7

Abbreviations: AUC_0–day22=area under the plasma concentration–time curve from time 0 to day 22; C_1 h=plasma concentration at 1 h after the end of infusion; C_day22=plasma concentration at day 22 of the cycle.

n indicates the number of patients included in the analysis.

^an=1.

^bn=8.

^cn=6.

^dn=2.

^en=5.

^fn=4.