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. 2010 Jul 13;103(3):354–361. doi: 10.1038/sj.bjc.6605793

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Copyright © 2010 Cancer Research UK

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Effects of TS depletion on the expression of Bcl-2 and IAP family members and on the release of mitochondrial proteins into the cytosol in lung cancer cells. (A) The indicated cell lines were transfected with nonspecific (NS) or TS-1 siRNAs for 72 h, after which cell lysates were prepared and subjected to immunoblot analysis with antibodies to the indicated proteins. (B) SBC-3 cells were transfected with NS or TS-1 siRNAs for 24, 48, or 72 h, after which a cytosolic fraction was prepared and subjected to immunoblot analysis with antibodies to cytochrome c, Smac/Diablo, Omi/HtrA2, and β-actin. Transfection with the NS siRNA had no substantial effects on the abundance of Bcl-2 or IAP family proteins or on the release of mitochondrial proteins into the cytosol, compared with untreated cells.