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. Author manuscript; available in PMC: 2011 Apr 2.
Published in final edited form as: Circ Res. 2010 Feb 18;106(6):1117–1128. doi: 10.1161/CIRCRESAHA.109.212530

Figure 6. Chronic administration of MG132 suppresses AMPKα2 deletion-enhanced oxidative stress, in vivo.

Figure 6

(A) Representatives of immunohistochemical staining and quantifications for 3-NT, MDA, and HNE positive proteins (original magnification ×400) in aortas from LDLr−/− and LDLr−/−/AMPKα2−/− mice. *P<0.05 vs. LDLr−/− control mice, #P<0.05 vs. LDLr−/−/AMPKα2−/− control mice. (B) The ROS productions were detected by DHE/HPLC in LDLr−/− and LDLr−/−/AMPKα2−/− mice aortas. *P<0.05 vs. LDLr−/− control mice. (C) The levels of 3-NT were measured by Western blot. *P<0.05 vs. LDLr−/− control mice, #P<0.05 vs. LDLr−/−/AMPKα2−/− control mice. (D) Effects of MG132 on endothelium-dependent vasorelaxation in LDLr−/− and LDLr−/−/AMPKα2−/− mice aortas. *P<0.05 vs. LDLr−/− control mice, #P<0.05 vs. LDLr−/−/AMPKα2−/− control mice. n=5–6 per group.