Table 2.

Characterized mutations within IN conferring resistance to RAL or EVG.

Mutations	IN			Virus		Refs
	3′-P	ST	Rce	Selection	RC
H51Y		++		EVG		[76]
H51Y/E92Q/S147G		+		EVG		[76]
H51Y/E92Q/S147G/E157Q		++		EVG		[76]
T66A	+	++		RAL/EVG	++	[63,77,78]
T66I	+++*	+++*	51–102X	DKA/EVG	++*	[29,38,79–87]
T66I/E92Q		−		EVG		[85,86]
L74M	+++	+++	1X1,2	DKA/EVG		[29,80,84,85,88]
E92Q	+++*	+++*	4–5X1,2	DKA/RAL/EVG	++	[66,76,78,88]
E92Q/S147G		+		EVG		[76]
E92Q/N155H				RAL	++*	[72,89]
E138K/Q148HRK				DKA/RAL	++	[72,87,90]
G140S	+++*	+	1X1,2	DKA/RAL	++	[61,71,78,89–93]
G140A	++	+	2–3X1	RAL		[71]
G140S/Q148H	++*	+++*	>50X1,2	RAL	+++	[61,66,72,94]
G140S/Q148K	++	+	10–25X1	DKA/RAL	++	[71,72,90]
G140S/Q148R	−	+	>25X1	DKA/RAL	++	[56,72,87]
G140A/Q148H	−	+	>25X1	RAL	+	[71,72]
G140A/Q148K	−	−	2–3X1	RAL	++	[71,72]
G140A/Q148R	+	+	>25X1	RAL	++	[71,72,95]
G140S/Q148H/S230N				RAL	+++	[89]
Y143R	+	++	>50X1	RAL	+	[56,62,93,96]
Y143C	+	+	>50X1	RAL	+	[62]
Y143R/G163R				RAL	++	[89]
S147G		+		EVG		[76]
Q148K	−	+*	50X1*	DKA/RAL/EVG	+	[28,29,71,72,87,90]
Q148R	+*	+	2–3X1	DKA/RAL/EVG	++	[71,72,78,85–87,90,95,97]
Q148H	−	+*	2–3X1,2	RAL	++*	[61,71,72,78,89,93]
Q148H/N155H				RAL	+	[89]
Q148K/G163R				RAL		[87]
N155H	+++*	+++*	5–10X1,2	DKA/RAL	++	[29,61,66,72,78,86,87,89,93–95,97,98]
E157Q		++		RAL/EVG		[76,99]
S230R	+++	+++		DKA/EVG		[80,85]

R^ce: resistance expressed as fold change in IC₅₀; RC: replication capacity.

Signs refer to activity compared to WT: − = 0–10%;

⁺= 10–40%;

⁺⁺= 40–80%;

⁺⁺⁺= 80–100%;

no entry = not tested.

¹RAL,

²EVG,

^*discordant data in literature (the highest value is presented).