Table 2.
Univariate assocations for risk of infection with new HPV types detected at 2nd and 3rd event
| Hazard Ratio (95% confidence interval) | ||
|---|---|---|
| 2nd event1 | 3rd event1 | |
| New cohort2 (vs. old) | 1.76 (1.5 – 2.05) | 2.29 (1.85 – 2.83) |
| Persistent HPV infection3 (vs. cleared) | 3.5 (2.97 – 4.15) | 3.51 (2.85 – 4.33) |
| Age (per year) | 0.92 (0.88 – 0.96) | 0.84 (0.78 – 0.92) |
| Years sexually active (per year) | 0.93 (0.89 – 0.97) | 0.89 (0.84 – 0.95) |
| Weekly drug use | 1.8 (1.01 – 3.2) | NS |
| Currently smoking cigarettes | NS | 1.23 (0.98 – 1.54) |
| Current oral contraceptive use | 0.86 (0.73 – 1.00) | 0.75 (0.61 – 0.94) |
| Months of medroxyprogesterone use (per month) | 1.01 (1.003 – 1.026) | 1.02 (1.009 – 1.032) |
| Irregular mense (greater than 36 days since last menstrual period) | 1.26 (1.02 – 1.56) | 1.38 (1.01 – 1.88) |
| # of new partners per month in last 8 months (per partner) | 1.08 (1.04 – 1.12) | 1.09 (1.05 – 1.13) |
| # of lifetime sexual partners (per partner) | 1.02 (1.007 – 1.03) | NS |
| Recent4 history of anal sex | 1.26 (0.99 – 1.6) | 1.27 (0.94 – 1.7) |
| Recent4 history of douching | NS | 1.26 (0.98 – 1.64) |
| African American (vs White) | 1.69 (1.33 – 2.4) | NS |
| Asian/Pacific Islander (vs White) | 1.35 (1.06 – 1.72) | NS |
| Reported history of infections | ||
| Recent4 Bacterial Vaginosis | 1.5 (1.03 – 2.12) | 1.55 (1.0 – 2.39) |
| Recent4 N. gonorrhoeae | 5.08 (2.40 – 10.8) | 7.87 (1.89 – 32.74) |
| Recent4 C. trachomatis | 1.5 (0.99 – 2.24) | 2.07 (1.23 – 3.48) |
| Recent4 HSV | 2.07 (1.39 – 3.07) | NS |
| Recent4 STI5 | 1.8 (1.3 – 2.6) | 1.74 (1.08 – 2.81) |
| Reported4 history of ever having an STI5 | 1.33 (1.13 – 1.56) | NS |
| Recent4 STI, but cannot remember name | 7.5 (2.35 – 23.89) | NS |
| Recent4 reported genital warts | NS | 1.65 (.98 – 2.77) |
| Laboratory-documented infections | ||
| C. trachomatis (current) | NS | NS |
| C. trachomatis (previous visit)6 | 2.1 (1.4 – 3.11) | 3.02 (1.88 – 4.87) |
| C. trachomatis (cumulative history) | 1.59 (1.24 – 2.03) | 1.72 (1.33 – 2.23) |
| N. gonorrhoeae (current) | NS | 7.79 (1.87 – 32.5) |
| N. gonorrhoeae (previous visit)6 | 4.78 (2.3 – 10.14) | NS |
| N. gonorrhoeae (cumulative history) | 1.68 (0.95 – 2.97) | NS |
| Bacterial vaginosis (current) | 1.53 (1.06 – 2.21) | 1.99 (1.36 – 2.89) |
| Bacterial vaginosis (previous visit)6 | 1.59 (1.1 – 2.31) | 1.69 (1.12 – 2.54) |
| Bacterial vaginosis (cumulative history) | 1.56 (1.24 – 1.95) | 2.25 (1.77 – 2.85) |
| Any STI7 (current) | NS | NS |
| Any STI7 (previous visit)6 | 2.54 (1.79 – 3.61) | 2.62 (1.67 – 4.12) |
| Any STI7 (cumulative history) | 1.76 (1.37 – 2.15) | 1.60 (1.24 – 2.03) |
| Greater than WBC/hpf on wet mount (current) | 0.52 (0.26 – 1.04) | NS |
All subjects begin with a known initial HPV infection. 2 nd event reflect the visit at which an HPV type is detected which was not previously detected at the initial visit. 3 rd event reflects the visit after the 2 nd event in which a new HPV type was detected.
New cohort reflects those women recruited starting in 2000; old cohort reflects women recruited from 1990 – 1994.
For incident 2 nd event, persistence is defined as persistence of a type found at initial HPV event to 2 nd event. For 3 rd event, persistence is defined as persistence of a type found at the 2 nd event to 3 rd event.
Recent is reported to have infection/behavior since the last visit. For HSV, refers to new or recurrent infection
Sexually transmitted infections (STI) include C. trachomatis, N. gonorrhoeae, T. vaginalis, and an infection that the subject cannot remember the name.
Includes any interim visits between previous and current visit but excludes current.
Includes C. trachomatis, N. gonorrhoeae, and T. vaginalis.
NS = not significant
Other variables found not significant (p greater than 0.1) include yeast (history or lab documented), condom use, T. vaginalis (history or lab), herpes simplex virus (lab), alcohol or marijuana use, smoking history, monogamy, menarchael age, reported number of STI at baseline, and pregnancy history.