Table 3.
Multivariate analysis for risk of newly acquired HPV infection at 2nd and 3rd new type events
| Model 11,4, 5 | 2nd Event | 3rd Event | ||
|---|---|---|---|---|
| Hazard Ratio (95% confidence interval) | P | Hazard Ratio (95% confidence interval) | p | |
| Persistent HPV from prior event | 4.51 (3.78 – 5.37) | <0.0001 | 3.37 (2.69 – 4.23) | <0.0001 |
| Age (per year) | 0.95 (0.91 – 0.98) | 0.005 | 0.91 (0.86 – 0.96) | 0.0004 |
| African-American (vs White) | 1.65 (1.30 – 2.08) | <0.0001 | 1.22 (0.90 – 1.66) | 0.19 |
| Mixed race (vs. White) | 1.82 (1.18 – 2.81) | 0.007 | 1.22 (0.72 – 2.06) | 0.46 |
| Recent anal sex | 1.28 (1.00 – 1.64) | 0.05 | 1.50 (1.09 – 2.06) | <0.01 |
| Number of new partners in past 8 months (per partner) | 1.10 (1.05 – 1.15) | <0.0001 | 1.09 (1.05 – 1.14) | <0.0001 |
| Laboratory diagnosis of Bacterial Vaginosis at previous visit | 1.60 (1.07 – 2.39) | 0.03 | 0.99 (0.63 – 1.56) | 0.95 |
| Laboratory diagnosis of an STI2 at previous visit | 1.47 (1.00 – 2.17) | 0.05 | 2.10 (1.30 – 3.39) | 0.003 |
| Greater than 10 PMN/hpf at current visit (vs ≤ 10 PMNs) | 0.39 (0.19 – 0.79) | 0.009 | 1.04 (0.51 – 2.13) | 0.92 |
| Model 23,4,5 | H.R. (95% C.I.) | P | H.R. (95% C.I.) | p |
| Persistent HPV from prior event | 4.51 (3.78 – 5.38) | <0.001 | 3.45 (2.75 – 4.32) | <0.0001 |
| Age (per year) | 0.94 (0.90 – 0.98) | 0.002 | 0.91 (0.86 – 0.96) | 0.0004 |
| African-American (vs White) | 1.70 (1.34 – 2.15) | <0.0001 | 1.25 (0.93 – 1.69) | 0.14 |
| Mixed race (vs. White) | 1.85 (1.20 – 2.86) | 0.005 | 1.19 (0.70 – 2.01) | 0.51 |
| Recent anal sex | 1.28 (1.00 – 1.65) | 0.05 | 1.47 (1.06 – 2.03) | 0.02 |
| Number of new partners in past 8 months (per partner) | 1.10 (1.00 – 1.15) | <0.0001 | 1.10 (1.05 – 1.14) | <0.0001 |
| Recent reported STI2 | 1.42 (1.00 – 2.04) | 0.05 | 1.83 (1.12 – 2.94) | 0.02 |
| Recent reported HSV | 2.43 (1.58 – 3.73) | <0.0001 | 1.50 (.88 – 2.57) | 0.14 |
1
Model 1 includes laboratory documented STI history only.
2
STI variables reflect C. trachomatis, N. gonorrhoeae, and T. vaginalis.
3
Model 2 uses questionnaire reported STI history only.
4
Adjusted for cohort and prevalent vs. incident HPV at 1 st detected visit.
5
Latino, Native American, and Asian Pacific Islander vs. white were not significant and not shown in the model.
6
Likelihood ratio statistic for model 1 = 325.77 (p < 0.0001) for 2 nd event and 190.04 (p < 0.0001) for 3 rd event.
7
Likelihood ratio statistic for model 2 = 311.69 (p < 0.0001) for 2 nd event and 187.23 (p < 0.0001) for 3 rd event