Table 4. Root mean-squared difference between CV and external validation performance (MCC) for different decision thresholds.

End point	Decision threshold
	A priori, 0.5	Best cross- validation
Breast cancer, pathological complete response (D)	0.045	0.087
Breast cancer, estrogen receptor status (E)	0.052	0.064
Multiple myeloma, overall survival (F)	0.040	0.033
Multiple myeloma, event-free survival (G)	0.036	0.041
Multiple myeloma, positive control (H)	0.024	0.024
Multiple myeloma, negative control (I)	0.033	0.033
Neuroblastoma, overall survival (J)	0.043	0.045
Neuroblastoma, event-free survival (K)	0.027	0.021
Neuroblastoma, positive control (L)	0.027	0.027
Neuroblastoma, negative control (M)	0.038	0.040

The values given in bold indicate lower error for each end point.