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. Author manuscript; available in PMC: 2010 Aug 11.
Published in final edited form as: J Clin Pathol. 2010 Jul;63(7):579–584. doi: 10.1136/jcp.2010.076125

Figure 1.

Figure 1

Expression of MUC4 in normal epidermis, cancer adjacent normal skin and chronically inflamed skin tissue. (A) MUC4-negative normal skin epidermis. (B) Cancer adjacent normal skin tissue from the right elbow of a 40-year-old woman, showing MUC4 expression diffusely throughout the entire thickness of the epidermis, most prominently in the stratum spinosum. Note the melanin pigment granules present in cells of the stratum basalis. (C) Cancer adjacent normal skin tissue from the right hand of a 75-year-old woman. MUC4 expression is confined to the stratum corneum, with less intense staining in a few cells of the stratum granulosum. (D,E) Chronic inflammation of the left foot (D) and right thigh (E) with keratinisation of the squamous epithelium. MUC4 is expressed by the stratum corneum and stratum granulosum of the epidermis. MUC4 expression in all cases is in the cytoplasm and the membrane. (A–E) Magnification ×200 to demonstrate subcellular localisation of MUC4; insets, low magnification (×40).