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. Author manuscript; available in PMC: 2010 Aug 11.
Published in final edited form as: J Clin Pathol. 2010 Jul;63(7):579–584. doi: 10.1136/jcp.2010.076125

Figure 3.

Figure 3

Expression of MUC4 in cutaneous squamous cell carcinoma (SCC) by grade of tumour. (A) Well-differentiated SCC showing strong MUC4 expression in the malignant cells, and particularly in the keratin pearls (B). (C) MUC4 expression is equally intense but with fewer positive cells in moderately differentiated SCC. (D) Keratin pearls are evident and show strong MUC4 expression, similar to that seen in well-differentiated SCC. (E) Poorly differentiated SCC showing moderate-to-weak MUC4 expression, together with an absence of keratinisation. (F) A high-power view shows groups of malignant cells with mostly weak MUC4 expression in the cytoplasm and membrane, and few cells with moderate MUC4 positivity. (A,C,E) Magnification ×100, and (B,D,F) magnification ×200, to demonstrate subcellular localisation of MUC4; insets, low magnification (×40).