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. Author manuscript; available in PMC: 2011 Apr 6.
Published in final edited form as: Pure Appl Chem. 2010 Apr 6;82(9):1735–1748. doi: 10.1351/pac-con-09-11-14

Scheme 8.

Scheme 8

Reagents and Conditions: (a) 2-iodotrifluoroacetanilide, Pd(OAc)2, Et3N, NMP, μW, 30 min, 125 °C, 45% (2:1 regioisomers: 66 major); (b) I2, PPh3, Imidazole, CH2Cl2, 86%; (c) 2.0 M CH3NH2/THF, 50 °C, 81%; (d) 4 N HCl/Dioxane, −10 °C, 98%.