Table 1.
Genotypic resistance results for 19 HIV-infected children on long-term ART, Haydom Lutheran Hospital, Tanzania
| ID no. | Sex | Age at ART start (years) | ART regimen: initial (currenta) | Duration of ART (months) | Most recent CD4 cell count (cells/mm3)b | Viral load (copies/mL) | NRTI mutations | NNRTI mutations | Resistance to antiretroviral drugs |
|---|---|---|---|---|---|---|---|---|---|
| 1 | M | 6 | ZDV/3TC/EFV (d4T/3TC/NVP) | 40 | 595 | 640 000 | M184V | V108I, Y181CV | 3TC, FTC, all NNRTIs |
| 2 | M | 7 | d4T/3TC/NVP | 11 | 667 | 300 000 | M184V | G190S | 3TC, FTC, all NNRTIs |
| 3 | M | 5 | ZDV/3TC/NVP (d4T/3TC/NVP) | 18 | 650 | 220 000 | D67N, K70R, M184V, T215Y, K219EQ | K101E, Y181C, G190A | all NRTIs and NNRTIs |
| 4 | M | 11 | d4T/3TC/NVP | 58 | 550 | 28 000 | V75I, M184V, T215Y | K103N, V108I | all NRTIs, NVP, EFV |
| 5 | M | 3 | d4T/3TC/NVP | 59 | 575 | 23 000 | M184V | K101E, G190A | 3TC, FTC, all NNRTIs |
| 6 | M | 5 | ZDV/3TC/EFV (d4T/3TC/NVP) | 25 | 899 | 6400 | M184V | Y181C | 3TC, FTC, all NNRTIs |
| 7 | F | 2 | ZDV/3TC/NVP | 35 | 748 | 5000 | M184V | Y181C | 3TC, FTC, all NNRTIs |
| 8 | F | 4 | d4T/3TC/NVP (ZDV/3TC/EFV) | 56 | 264 | 1200 | D67N, K70R, M184V, L210W, T215F, K219Q | V179T, G190A | all NRTIs and NNRTIs |
| 9 | M | 14 | d4T/3TC/EFV (d4T/3TC/NVP) | 37 | 398 | 980 | M184V | K103N, V108I | 3TC, FTC, NVP, EFV |
| 10 | M | 8 | d4T/3TC/NVP | 54 | 713 | 870 | M184V | K103N | 3TC, FTC, NVP, EFV |
| 11 | F | 2 | ZDV/3TC/NVP (d4T/3TC/NVP) | 36 | 496 | 350 | A64V, M184V | V90I, K103N | 3TC, FTC, NVP, EFV |
| 12 | F | 2 | ZDV/3TC/NVP (ZDV/3TC/EFV) | 27 | >2000 | NDc | none | none | none |
| 13 | M | 5 | ZDV/3TC/NVP (d4T/3TC/NVP) | 51 | 820 | 40 | — | — | — |
| 14 | F | 9 | d4T/3TC/NVP | 61 | 712 | <40 | — | — | — |
| 15 | M | 10 | ZDV/3TC/NVP (d4T/3TC/NVP) | 53 | 800 | <40 | — | — | — |
| 16 | F | 5 | ZDV/3TC/EFV (d4T/3TC/NVP) | 43 | 1261 | <40 | — | — | — |
| 17 | F | 5 | ZDV/3TC/EFV (d4T/3TC/NVP) | 40 | 1050 | <40 | — | — | — |
| 18 | F | 3 | ZDV/3TC/NVP (d4T/3TC/EFV) | 23 | 1599 | <40 | — | — | — |
| 19 | M | 5 | d4T/3TC/NVP | 11 | 672 | <40 | — | — | — |
d4T, stavudine; ZDV, zidovudine; 3TC, lamivudine; FTC, emtricitabine; NVP, nevirapine; EFV, efavirenz.
aOnly specified if different from initial regimen.
bWithin ±6 months of viral load/resistance testing.
cND, not done; venipuncture failed and dried blood spots were used for resistance testing.