Fig. 3.

Protective effects of CocE against cocaine-induced toxicity. Wild-type or mutant CocE (mg) were administered to mice intravenously 1 min before cocaine administration (mg/kg, i.p.). Dose-response curves of cocaine-induced lethality in the absence or presence of wt-CocE or mutants were plotted. Each data point represents the percentage of mice (n = 6 for each dosing condition) exhibiting cocaine-induced lethality.