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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Cancer Biol Ther. 2010 Feb 1;9(4):321–329. doi: 10.4161/cbt.9.4.10750

Figure 4.

Figure 4

Response of pancreatic cancer cell lines with deficient and proficient DNMT1 to the DNA methylation inhibitor 5-Aza-dC and tea polyphenol (EGCG). (A) Effect of increasing concentration of 5-Aza-dC (0, 1, and 10 uM) and EGCG (0, 5, and 25 uM) on expression of DNMT1 protein. GAPDH used as a loading control; (B) Effect of DNMT1 on cell viability. Cells were treated with indicted doses of 5-Aza-dC for 96 h (fresh drug added every 48 h) and then cell viability was determined using the MTS assay.