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. Author manuscript; available in PMC: 2011 Sep 1.
Published in final edited form as: J Sleep Res. 2010 Apr 7;19(3):384–393. doi: 10.1111/j.1365-2869.2010.00833.x

Fig. 1.

Fig. 1

Twenty-four hour sleep-wake state effects on days 1, 7, and 14, of twice daily treatment with Esz (10 mg/Kg), compared to Veh. Esz was administered at ZT 3 and 9. Esz treatment resulted in significant increases in NREM and decreases in wake for 6 hrs on day 1 of treatment, from ZT 5 through ZT10. On day 1, from ZT0 to ZT12, total NREM was: Esz, 44.9±1.3%, Veh, 34.4±1.8% (p < 0.001) and wake was: Esz, 50.2±1.1, Veh, 58.7±1.4 (p<0.001). No significant effects of Esz on sleep-wake stages were found after ZT12 on day 1, or on either days 7 or 14. (N=8 in both Esz and Veh groups)