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. Author manuscript; available in PMC: 2011 Mar 26.
Published in final edited form as: Chem Biol. 2010 Mar 26;17(3):285–295. doi: 10.1016/j.chembiol.2010.02.007

Figure 5. FIIN-1 inhibits FGFR2 and pro-survival signaling pathways, and inhibits FGFR2-dependent cell growth.

Figure 5

(A) FIIN-1 inhibited pro-survival signaling pathways in the FGFR2-amplified gastric cancer cell lines including KATO III and SNU-16 and in the other cancer cell lines that were previously shown to be independent of FGFR signaling for survival. Cells were treated for 6 hours with 200 nM of each compound. (B) Proliferation of the endometrial carcinoma cell lines (MFE-296, AN3CA) that express activating FGFR2 mutants were abrogated by FGFR inhibitors, while Hec-1B cells that express WT FGFR2 showed no sensitivity to the inhibitors.