Figure 1.
Crystal structure of CLC-ec1. (a) Ribbon representation of the CLC-ec1 homodimer viewed from the plane of the membrane. The two subunits are coloured in brown and blue and the chloride ions are represented as green spheres. (b) The chloride binding region for the WT CLC-ec1 and (c) the E148Q mutant. The residues S107, E148 and Y445 are highlighted in blue. (PDB accession codes WT: 1OTS, E148Q: 1OTU)