Table 3.
Antimicrobial Data for 1, 1a, 4-8.
| Agar disk diffusion (μg/disk)a | MIC50 (μg/mL) | |||||||
|---|---|---|---|---|---|---|---|---|
| compound | S. aureus | MRSA | E. faecium | VREF | S. aureus | MRSA | E. faecium | VREF |
| 1 | 2 | 2 | 2 | 2 | 1.8 ± 0.6 | 1.5 ± 0.7 | 3.8 ± 1.9 | 2.9 ± 0.8 |
| 1a | NAb | NA | NA | NA | — c | — | — | — |
| 4 | 25 | 25 | 25 | 25 | > 25 | 20 ± 6.5 | > 50 | > 25 |
| 5 | 25 | 10 | 10 | 10 | 11 ± 3.8 | 8.9 ± 2.8 | > 25 | > 25 |
| 6 | 10 | 10 | 10 | 10 | 5.3 ± 2.0 | 4.2 ± 1.3 | > 25 | 9.5 ± 3.0 |
| 7 | NA | NA | NA | NA | 17 ± 5.4 | 12 ± 3.1 | > 50 | 25 ± 7.3 |
| 8 | 5 | 5 | 10 | 10 | 4.5 ± 1.4 | 4.7 ± 1.4 | > 25 | 9.4 ± 2.8 |
a
Lowest concentrations leading to 7-10 mm zones of inhibition
b
NA, no zone of inhibition observed at 25 μg/disk
c
—, not tested.