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. Author manuscript; available in PMC: 2010 Aug 12.
Published in final edited form as: Science. 2009 Oct 29;326(5958):1369–1373. doi: 10.1126/science.1178535

Fig. 6. Conformation and nascent polypeptide chain-interactions of the RNC-bound mammalian Sec61 complex.

Fig. 6

(A) Fit of the Sec61 model (red ribbons) into the density (grey transparent mesh). Side views on the lateral gate (top) and on the cytosolic loops L6 and L8 (bottom). (B) Crystal structure of the M. jannaschii SecYEβ complex (grey) (13) superimposed on Sec61 model. The C- and N-terminal halves are shown in red and blue, transmembrane (TM) helix 7 in yellow and TM helix 2 in cyan. β- (dark red) and γ-subunits (SecE, magenta) are indicated. (C) Side view (top, as in A) and top view (bottom, as in B) of the Sec61 model and extra density for the nascent polypeptide chain (green). (D) Side view as in (C) (top) but rotated to focus on the nascent chain (green). Color code as in Fig. 2E. (E) Schematic representation of an actively translating and translocating eukaryotic ribosome-Sec61 complex with a single copy acting as PCC.