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. Author manuscript; available in PMC: 2010 Aug 12.
Published in final edited form as: J Immunol. 2009 Nov 4;183(11):6989–6997. doi: 10.4049/jimmunol.0901386

Figure 12. siRNA against TRIF, MDA5, but not RIG-I reduced RV1B-induced IRF3 dimerization.

Figure 12

A. RIG-I, MDA5, TRIF siRNA or non-targeting siRNA was transfected into BEAS-2B. After transfection, cells were infected with RV1B, UV-irradiated RV1B or sham. After infection, cell lysates were probed with anti-IRF3 antibody. Poly I:C served as a positive control. B. IRF3 dimer to monomer ratio was quantified by densitometry. (The blot shown is a representative of two experiments.)