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. Author manuscript; available in PMC: 2010 Aug 12.
Published in final edited form as: Pediatr Res. 2009 May;65(5 Pt 2):84R–90R. doi: 10.1203/PDR.0b013e31819dc2f9

Figure 2. Comparison of α-smooth muscle actin (α-SMA) immunostaining in human preterm lung specimens.

Figure 2

(A) Control non-ventilated infant at 23 wk GA; (B) Other pneumonia case at 24 wk GA ventilated for 2 d; and (C) Ureaplasma-infected infant at 26 wk GA ventilated for 20 d. Lung sections were incubated with anti-α̃SMA antibody and counterstained with hematoxylin. Negative controls were processed in the absence of primary antibody (D) (Magnification 200x). α̃SMA immunoreactive cells were noted surrounding vessel walls (arrows) in (A) and distributed in a pattern of thickened clusters of cells often surrounding terminal airways in other pneumonia and Ureaplasma cases (B and C). The extent of myofibroblast accumulation and percent of lung involvement was greater in Ureaplasma cases than in other pneumonia cases. Reprinted from Viscardi et al. Pediatr Dev Pathol 9:143–151, Copyright © 2006 Society for Pediatric Pathology and the Paediatric Pathology Society, with permission.