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. Author manuscript; available in PMC: 2010 Sep 1.
Published in final edited form as: Bioconjug Chem. 2009 Sep 14;20(10):1853–1859. doi: 10.1021/bc900217h

Figure 2.

Figure 2

Reaction scheme for creating click-conjugated dendrons employed in the in vitro studies. (i) glutaric anhydride, MeOH, 24 hrs, r.t. (ii) EDC, c(RGDyK), H2O/DMSO, 2 days, r.t. (iii) Alexa Fluor 488 azide OR biotin-dPEG3+4-azide OR MTX-azide(5) OP azide-G2(AF)2(OH)24 (9) sodium ascorbate, copper (II) sulfate, H2O, 36 hours, r.t.