Skip to main content
. Author manuscript; available in PMC: 2010 Sep 1.
Published in final edited form as: Bioconjug Chem. 2009 Sep 14;20(10):1853–1859. doi: 10.1021/bc900217h

Figure 6.

Figure 6

The antiproliferative effect of MTX-G3(COOH)11.9(RGD)4.1 (6). The dose-dependent inhibition of cell growth of 6 was compared to free MTX and alkyne-G3(COOH)11.9(RGD)4.1 control (3) using a XTT assay. The cells were treated with different concentrations of free MTX or dendron conjugates for 72 hours with a replenishing of 100 μL medium and the conjugates after 48 hours. 6 and MTX were determined to not be significantly different for concentrations greater than or equal to 0.25 μM. The effects of 6 and MTX were not significantly different for concentrations greater than 0.125 μM. 6 had a significantly greater effect on cell viability versus 3 for concentrations greater than 0.125 μM.