Figure 6.

ECS volume measurement in tumor slices. Slices cut from a 5-mm-diameter subcutaneous tumor in a mouse at 12 days after injection of LLC1 cells. (A) Histology showing hematoxylin and eosin staining of a tumor slice in a direction transverse to the skin surface. Squares indicate sites of microfiberoptic insertion. Bar: 500 μm. Panels a–f show high-magnification views of microfiberoptic insertion areas. Bar: 50 μm. (B) Summary of α-values at different depths from the tumor surface (SE, 8–10 slices per location, ^∗p < 0.05, ^∗∗p < 0.001 compared with α at 50 μm). Representative of studies in tumors from four mice.