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. 2010 Aug 9;99(4):1221–1230. doi: 10.1016/j.bpj.2010.06.019

Figure 1.

Figure 1

Putative SNAP-25 response to oxidative stress. (A) “Naked” SNAP-25 with its two SNARE domains and four cysteines (C85, C88, C90, and C92). (B) In vivo, SNAP-25 is posttranslationally palmitoylated, which adds 1–4 palmitic acids to cysteines within the weak membrane-binding domain (MBD); palmitoylation of the middle two cysteines is shown. (C) Oxidation of SNAP-25 could result in disulfide bond formation between any of the free cysteines (one of six possibilities is shown). (D) A specific example of a SNAP-25 with the inner two cysteines palmitoylated and the outer cysteines disulfide-linked.