Table 1.
Summary of anomalies α and mean residence times τD for the indicated proteins at the permissive and nonpermissive temperature for VSVG ts045 folding
39.5°C | 32°C | ||
---|---|---|---|
GalNAc-T2 | α | 0.80 ± 0.01 | 0.78 ± 0.02 |
τD [ms] | 9 ± 0.53 | 13 ± 0.88 | |
n | 56 | 62 | |
VSVG ts045 | α | 0.61 ± 0.01 | 0.75 ± 0.01 |
τD [ms] | 14 ± 0.76 | 18 ± 0.75 | |
n | 63 | 87 | |
VSVG ts045(N336S) | α | 0.70 ± 0.02 | NA |
τD [ms] | 43 ± 4.87 | NA | |
n | 33 | NA |
Testing the significance of the change in α when shifting to 32°C via a Student's t-test yielded p = 0.363 (GalNAc-T2) and p = 1.8 × 10−14 (VSVG ts045).