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. Author manuscript; available in PMC: 2011 May 1.
Published in final edited form as: J Immunol. 2010 Mar 29;184(9):5172–5178. doi: 10.4049/jimmunol.0903759

Figure 6.

Figure 6

C57BL/6 NK cells can restore IFNγ production in infected MyD88−/− mice. 1.5 × 106 CFSE-labeled C57BL/6 NK cells were adoptively transferred into MyD88−/− mice before wt Lm infection. (A) At 24hpi, the transferred CFSE-labeled NK cells were clearly visible in the spleens of Lm-infected mice. (B) Transferred NK cells did not show evidence of proliferation with the first day after infection. In the total NK cell population infected MyD88−/− mice that received C57BL/6 NK cells (black line) did not exhibit NK cell proliferation compared to uninfected MyD88−/− mice that received C57BL/6 NK cells (shaded). This was apparent in both the total NK cell population and the population of NK cells gated as CFSE+. (C) IFNγ was undetectable in MyD88−/− and significantly higher in the sera of MyD88−/− mice that received the transferred C57BL/6 NK cells, as determined by the t-test (p=0.04).