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. Author manuscript; available in PMC: 2011 May 1.
Published in final edited form as: J Immunol. 2010 Mar 29;184(9):5172–5178. doi: 10.4049/jimmunol.0903759

Figure 8.

Figure 8

Inhibition of receptor-ligand binding impairs NK cell activation. (A) C57BL/6 or Rag1−/−/IL-15Rα−/− BMDC were infected with wt or Δhly Lm and co-cultured with C57BL/6 NWNA for 19hrs. IFNγ in supernatants was measured by ELISA. (B) C57BL/6 BMDC were infected with wt or Δhly Lm and co-cultured with NWNA. In parallel, BMDC infected with wt Lm were also treated with anti-mouse ICAM1 at 1μg/ml prior to addition of NWNA. Inhibition of ICAM1 severely attenuated the IFNγ response to infection as measured by ELISA.