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. 1971 Jul;50(7):1411–1420. doi: 10.1172/JCI106624

Deposition and clearance of 2 μ particles in the tracheobronchial tree of normal subjects—smokers and nonsmokers

Ruy V Lourenço 1, Mary F Klimek 1, Claudia J Borowski 1
PMCID: PMC292079  PMID: 5090057

Abstract

Deposition and clearance of inhaled particles of iron oxide labeled with 198Au were studied in 19 normal subjects (10 nonsmokers and 9 smokers). For this purpose, monodisperse aerosols of particles with a 2 μ diameter were produced in a spinning disc atomizer. Thoracic counts and images with a scintillation camera were begun immediately after inhalation of the aerosol and continued for 6 hr.

In all subjects, smokers and nonsmokers, the deposition of the particles was uniform throughout both lung fields, with approximately half of the particles deposited in the ciliated airways (tracheobronchial deposition) and half in the nonciliated airways (alveolar deposition).

Tracheobronchial clearance in nonsmokers occurred immediately after inhalation, first at a fast rate for particles deposited in the largest and most central airways, and then at a slower rate for particles from the smaller and more peripheral airways. Photoscintigrams showed that the particles cleared steadily with no retention in any area. The general pattern of clearance may be likened to a model of multiple conveyor belts with speed increasing from the peripheral to the central airways in such a way as to prevent “particle jams” at airway confluence points.

In smokers, tracheobronchial clearance was delayed for periods of 1-4 hr after inhalation. Furthermore, in contrast with the findings in nonsmokers, significant clearance was still occurring in many of the smokers in the 5th and 6th hr after inhalation. Also, photoscintigrams showed an abnormal accumulation of particles in the large airways several hours after inhalation of the aerosol.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALBERT R. E., ARNETT L. C. Clearance of radioactive dust from the human lung. AMA Arch Ind Health. 1955 Jul;12(1):99–106. [PubMed] [Google Scholar]
  2. ALBERT R. E., PETROW H. G., SALAM A. S., SPIEGELMAN J. R. FABRICATION OF MONODISPERSE LUCITE AND IRON OXIDE PARTICLES WITH A SPINNING DISK GENERATOR. Health Phys. 1964 Dec;10:933–940. doi: 10.1097/00004032-196412000-00010. [DOI] [PubMed] [Google Scholar]
  3. Albert R. E., Lippmann M., Briscoe W. The characteristics of bronchial clearance in humans and the effects of cigarette smoking. Arch Environ Health. 1969 May;18(5):738–755. doi: 10.1080/00039896.1969.10665482. [DOI] [PubMed] [Google Scholar]
  4. Albert R. E., Lippmann M., Spiegelman J., Liuzzi A., Nelson N. The deposition and clearance of radioactive particles in the human lung. Arch Environ Health. 1967 Jan;14(1):10–15. doi: 10.1080/00039896.1967.10664686. [DOI] [PubMed] [Google Scholar]
  5. Asmundsson T., Kilburn K. H. Mucociliary clearance rates at various levels in dog lungs. Am Rev Respir Dis. 1970 Sep;102(3):388–397. doi: 10.1164/arrd.1970.102.3.388. [DOI] [PubMed] [Google Scholar]
  6. BALLENGER J. J., DAWSON F. W., DERUYTER M. G., HARDING H. B. EFFECTS OF NICOTINE ON CILIARY ACTIVITY IN VITRO. Ann Otol Rhinol Laryngol. 1965 Jun;74:303–311. doi: 10.1177/000348946507400202. [DOI] [PubMed] [Google Scholar]
  7. BURROWS B., KASIK J. E., NIDEN A. H., BARCLAY W. R. Clinical usefulness of the single-breath pulmonucy diffusing capacity test. Am Rev Respir Dis. 1961 Dec;84:789–806. doi: 10.1164/arrd.1961.84.6.789. [DOI] [PubMed] [Google Scholar]
  8. Cress H. R., Spock A., Heatherington D. C. The localization of succinic dehydrogenase, cytochrome oxidase and adenosine triphosphatase in ciliated respiratory epithelium. J Histochem Cytochem. 1965 Nov-Dec;13(8):677–683. doi: 10.1177/13.8.677. [DOI] [PubMed] [Google Scholar]
  9. Dalhamn T. Effect of cigarette smoke on ciliary activity. Am Rev Respir Dis. 1966 Mar;93(3 Suppl):108–114. doi: 10.1164/arrd.1966.93.3P2.108. [DOI] [PubMed] [Google Scholar]
  10. KORY R. C., CALLAHAN R., BOREN H. G., SYNER J. C. The Veterans Administration-Army cooperative study of pulmonary function. I. Clinical spirometry in normal men. Am J Med. 1961 Feb;30:243–258. doi: 10.1016/0002-9343(61)90096-1. [DOI] [PubMed] [Google Scholar]
  11. Lippmann M., Albert R. E. The effect of particle size on the regional deposition of inhaled aerosols in the human respiratory tract. Am Ind Hyg Assoc J. 1969 May-Jun;30(3):257–275. doi: 10.1080/00028896909343120. [DOI] [PubMed] [Google Scholar]
  12. Luchsinger P. C., LaGarde B., Kilfeather J. E. Particle clearance from the human tracheobronchial tree. Am Rev Respir Dis. 1968 Jun;97(6):1046–1050. doi: 10.1164/arrd.1968.97.6P1.1046. [DOI] [PubMed] [Google Scholar]
  13. Morrow P. E., Gibb F. R., Gazioglu K. M. A study of particulate clearance from the human lungs. Am Rev Respir Dis. 1967 Dec;96(6):1209–1221. doi: 10.1164/arrd.1967.96.6.1209. [DOI] [PubMed] [Google Scholar]
  14. NEEDHAM C. D., ROGAN M. C., McDONALD I. Normal standards for lung volumes, intrapulmonary gas-mixing, and maximum breathing capacity. Thorax. 1954 Dec;9(4):313–325. doi: 10.1136/thx.9.4.313. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. TOIGO A., IMARISIO J. J., MURMALL H., LEPPER M. N. Clearance of large carbon particles from the human tracheobronchial tree. Am Rev Respir Dis. 1963 Apr;87:487–492. doi: 10.1164/arrd.1963.87.4.487. [DOI] [PubMed] [Google Scholar]
  16. Thomson M. L., Short M. D. Mucociliary function in health, chronic obstructive airway disease, and asbestosis. J Appl Physiol. 1969 May;26(5):535–539. doi: 10.1152/jappl.1969.26.5.535. [DOI] [PubMed] [Google Scholar]
  17. WAGNER H. N., Jr, LOPEZ-MAJANO V., LANGAN J. K. CLEARANCE OF PARTICULATE MATTER FROM THE TRACHEOBRONCHIAL TREE IN PATIENTS WITH TUBERCULOSIS. Nature. 1965 Jan 16;205:252–254. doi: 10.1038/205252a0. [DOI] [PubMed] [Google Scholar]
  18. Wynder E. L., Goodman D. A., Hoffmann D. Ciliatoxic components in cigarette smoke. 3. In vitro comparison of different smoke components. Cancer. 1965 Dec;18(12):1652–1658. doi: 10.1002/1097-0142(196512)18:12<1652::aid-cncr2820181222>3.0.co;2-5. [DOI] [PubMed] [Google Scholar]

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