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. 2010 Mar 30;87(4):665–674. doi: 10.1093/cvr/cvq102

Figure 4.

Figure 4

H9c2 cardiomyoblasts treated with 28 mmol/L glucose resulted in cell death that was mediated via MCPIP-induced ER stress. (A) H9c2 cardiomyoblasts were treated with 28 mmol/L glucose and with/without 100 µM TUDC or 50 µM 4-PBA. Cells were then evaluated for cell death using trypan blue (left; ŧP < 0.05) or cell viability evaluated using MTT assay (right; *P < 0.03). (B and C) Cardiomyoblasts were treated with 28 mmol/L glucose with/without siRNA specific for IRE1 or with non-specific siRNA. Cell death was evaluated using trypan blue (*P < 0.03).