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. 2010 May 21;87(4):656–664. doi: 10.1093/cvr/cvq148

Figure 5.

Figure 5

Reduction in endogenous miR-146a ameliorated Dox-induced apoptosis in NRCMs. (A) qRT-PCR analysis for miR-146a in NRCMs, infected with control-decoy (no binding site) or decoy-miR-146a (anti-miR-146a × 6) using lentivirus vector. Values are the means ± SE of three independent experiments (##P < 0.05). (B) Immunoblotting for ErbB4 in NRCMs infected with control-decoy or decoy-miR-146a. (C) Densitometry for ErbB4 in NRCMs infected with control-decoy or decoy-miR-146a. Values are the means ± SE of four independent experiments (#P < 0.05). (D) Immunoblotting for ErbB4, bcl-2, and cleaved caspase 3 in NRCMs infected with control or decoy gene in the presence or absence of Dox for the indicated time periods. (E) Densitometry for ErbB4 in NRCMs infected with control or decoy gene in the presence or absence of Dox. Values are the means ± SE of four independent experiments (#P < 0.05). (F) Densitometry for cleaved caspase 3 in NRCMs infected with control or decoy gene in the presence or absence of Dox. Values are the means ± SE of four independent experiments (#P < 0.05).