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. 2010 Aug 12;5(8):e12112. doi: 10.1371/journal.pone.0012112

Figure 1. HR deficiency of Rad21+/− cells.

Figure 1

A. Clonogenic survival of WT and isogenic Rad21+/− ES cells following IR. B. Clonogenic survival of Rad21+/− ES cells following MMC indicated that Rad21+/− ES cells were more sensitive to MMC than WT ES cells. C. Gene targeting efficiency in Rad21+/− ES cells. Rad54−/− and its isogenic parental 1B10 ES cell line were used as gene targeting-defective and -proficient controls, respectively. D. SCE frequency in WT and isogenic Rad21+/− MEFs following treatment with 6 µM MMC. Red arrowheads indicate SCEs. Inserts: enlarged images of boxed regions. The number of metaphase spreads scored: WT n = 19; Rad21+/− n = 29. Horizontal bars represent the respective means.