Figure 5. Comparison between GO term/KEGG pathway prediction and DRSC RNAi screening hits.

A–B, GO/KEGG predictions matched with RNAi screen results compared to randomized RNAi screen data. C–E, individual pathway/function predictions matched with RNAi screen results compared to randomized RNAi screen data. For comparison, we show performance of a supervised machine-learning model trained using the same algorithm and datasets except that it aggregates all GO terms/KEGG pathways in its training as has been traditionally done.