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. 2010 Aug 12;5(8):e12119. doi: 10.1371/journal.pone.0012119

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Briatore et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A1,A2) Confocal images showing the distribution of GABA_ARα1 (green) and GABA_ARγ2 (red) in the cerebellar cortex of control (A1) and PC-Δα1 mice (A2). Note that in both conditions most GABA_ARγ2-positive clusters colocalize with the α1 subunit. A few clusters labelled for GABA_ARγ2 but not for GABA_ARα1 likely represent synapses containing α3-GABA_ARs. No surface labelling is visible in Purkinje cells (Pc) of PC-Δα1 mice, whereas MLIs (asterisks) are recognized by extrasynaptic labelling of the α1 subunit (A2). Double-labelled clusters (yellow) identify postsynaptic GABA_AR aggregates on the cell body and the dendrites of MLIs (A2). (B1) Clustered distribution of GABA_ARα1 (green) in control Purkinje cells labelled for Car8 (red). (B2,B3) GABA_AR clusters (B2: GABA_ARα1; B3: GABA_ARγ2) are not visible in Purkinje cells of PC-Δα1 mice. Scale bars: 15 µm.