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. 2010 Aug 12;6(8):e1000883. doi: 10.1371/journal.pcbi.1000883

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Success rates (A), average fixation times (B), and average viral reductions (C) are shown as functions of the genetic barrier (x-axis) for a range of acceleration factors (). A factor stands for a constant boost (of percent) to the proliferation rate of P cells in comparison to the proliferation rate of U cells. Different colors depict different values, with black depicting the default case (i.e., no enhancement). Each point summarizes the outcomes of 500 simulation runs with default parameter values, similar to Figure 4. Success rates consistently improve as a consequence of proliferation enhancement (A), but when the virus escapes, fixation is generally expedited (B). Major improvements in viral reductions take place before fixation occurs (C).

Inline graphic — Success rates (A), average fixation times (B), and average viral reductions (C) are shown as functions of the genetic barrier (x-axis) for a range of acceleration factors (). A factor stands for a constant boost (of percent) to the proliferation rate of P cells in comparison to the proliferation rate of U cells. Different colors depict different values, with black depicting the default case (i.e., no enhancement). Each point summarizes the outcomes of 500 simulation runs with default parameter values, similar to Figure 4. Success rates consistently improve as a consequence of proliferation enhancement (A), but when the virus escapes, fixation is generally expedited (B). Major improvements in viral reductions take place before fixation occurs (C).