Table 2.
Association analysis of GIP SNPs with Type 2 Diabetes
| rs2291725 | rs2291726 | |
|---|---|---|
| Major allele | A | G |
| Minor allele | G | A |
| Controls | ||
| n | 998 | 1000 |
| Major homozygous | 325 | 297 |
| Hetrozygous | 481 | 472 |
| Minor homozygous | 192 | 231 |
| Major allele frequency | 0.57 | 0.53 |
| Minor allele frequency | 0.43 | 0.47 |
| HWE (P -value) | 0.555 | 0.100 |
| Cases (T2DM) | ||
| n | 989 | 1000 |
| Major homozygous | 326 | 283 |
| Hetrozygous | 458 | 501 |
| Minor homozygous | 205 | 216 |
| Major allele frequency | 0.56 | 0.53 |
| Minor allele frequency | 0.44 | 0.47 |
| HWE (P -value) | 0.060 | 0.837 |
| Tests for association (C.I.: 95% confidence interval) | ||
| Odds ratio | 1.022 | 0.998 |
| Allele frequency | 0.728 | 0.974 |
| Dominant model | 0.850 | 0.490 |
| Recessive model | 0.406 | 0.421 |
n: total number of subjects
HWE - Hardy-Weinberg equilibrium