Figure 4. Absence of CCR2 signaling reduces TNF, NO and IFN-γ production during T. brucei infection.

At day 6 post infection, A) production of TNF, NO₂ (as measure of NO) and IFN-γ by unstimulated liver non-parenchymal cells after 24 hours of in vitro culture and B) percentages of CD4⁺IFN-γ⁺ and CD8⁺IFN-γ⁺ cells within the liver non-parenchymal cell fraction were determined in WT (white bars) and CCR2 KO (grey bars) mice. Data are shown as mean ± SEM of three individual mice of one of three independent experiments performed. *, significantly (p<0.05) lower compared to WT mice.