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. 2010 Mar 18;118(7):949–956. doi: 10.1289/ehp.0901525

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Inhibitory effect of As₂O₃ on creatine kinase activity and expression of MHC proteins during myogenic differentiation in C2C12 myoblasts; cells were cultured in growth medium (GM; day 0) or differentiation medium (DM) in the presence or absence of As₂O₃ (0.1, 0.3, or 0.5 μM) for 1, 2, or 4 days. (A) Activity of creatine kinase. (B) Expression of MHC proteins, examined by Western blotting; ERK was used as the loading control. Expression of MHC proteins was quantified by densitometric analysis. Data are mean ± SE for four independent experiments.

*p < 0.05 compared with arsenic-unexposed DM control.