Table 4. Multivariate analysis showing association of SNPs in BER genes with grade II-IV acute GVHD (table 4a), grade III-IV acute GVHD (table 4b) and chronic GVHD (table 4c).

*a: Grade II-IV acute GVHD
SNP	Gene	N eval	RR	95% CI	P value
rs6844176	RFC1	465	1.39	1.14-1.70	P=0.001
** b: Grade III-IV acute GVHD
rs6844176	RFC1	465	1.33	0.95-1.85	P=0.094
*** c: Chronic GVHD
rs1805410	PARP1	352	1.81	1.29-2.54	0.001

Shown are SNPs significant in multivariate analysis.

^*Other significant co-variates included donor type, diagnosis and disease status at transplant. Significant interaction was observed between rs6844176 and disease status at transplant.

^**No other clinical co-variates were significant.

^***Other significant co-variates included year of transplant and prior grade II-IV acute GVHD as a time dependent variable. No interactions were observed between rs1805410 and clinical covariates.