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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Leukemia. 2010 Jun 10;24(8):1437–1444. doi: 10.1038/leu.2010.132

Table 1.

Dose Escalation Schema

Dose Escalation Schedule
Dose Level Dose of Sorafenib Pts
Level 1 400 mg PO BID × 14 days out of 28 days 3
Level 2 400 mg PO BID × 21 days out of 28 days 9
Level 3 600 mg PO BID × 14 days out of 28 days 3
Level 4 600 mg PO BID × 21 days out of 28 days 0