Table 1.
Founders with excessive risk of descendants with JIA
| Founder | FSIR | P value | Descendants | JIA subtypes | Onset age Mean (range) | Female N (%) | ANA + N | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Total | with JIA | expected | S | R | P | O | E | Ps | U | ||||||
| 1 | 4.03 | 0.004 | 6266 | 6 | 1.5 | 3 | 3 | 4.4 (0.9–8.6) | 6 (100) | 3 | |||||
| 2 | 4.03 | 0.004 | 5272 | 5 | 1.5 | 2 | 2 | 1 | 4.3 (0.9–8.6) | 4 (80) | 3 | ||||
| 3 | 2.48 | 0.002 | 21517 | 13 | 5.6 | 1 | 2 | 2 | 5 | 3 | 8.1 (1.7–15.7) | 8 (62) | 4 | ||
| 4 | 3.50 | 0.005 | 5878 | 6 | 2.0 | 1 | 2 | 2 | 1 | 9.5 (1.1–15.7) | 5 (83) | 1 | |||
| 5 | 4.32 | 0.007 | 3915 | 5 | 1.2 | 2 | 2 | 1 | 9.5 (1.7–15.7) | 4 (80) | 1 | ||||
| 6 | 2.49 | 0.008 | 17389 | 10 | 4.0 | 3 | 4 | 2 | 1 | 9.2 (1.1–15.3) | 5 (50) | 1 | |||
| 7 | 2.88 | 0.008 | 10875 | 8 | 2.8 | 1 | 1 | 1 | 5 | 6.8 (2.2–12.5) | 3 (50) | 3 | |||
| 8 | 5.42 | 0.001 | 4646 | 6 | 1.1 | 1 | 2 | 2 | 1 | 9.9 (2.7–15.6) | 5 (83) | 3 | |||
| 9 | 7.04 | 0.0003 | 3455 | 6 | 0.9 | 1 | 2 | 2 | 1 | 9.9 (2.7–15.6) | 5 (83) | 3 | |||
| 10 | 6.85 | 0.0001 | 5185 | 7 | 1.0 | 1 | 2 | 3 | 1 | 8.1 (1.3–15.8) | 6 (86) | 3 | |||
| 11 | 4.23 | 0.002 | 7536 | 7 | 1.7 | 1 | 2 | 3 | 1 | 8.1 (1.3–15.8) | 6 (86) | 3 | |||
| 12 | 4.43 | 0.006 | 5726 | 5 | 1.1 | 1 | 1 | 3 | 4.8 (1.3–13.1) | 4 (80) | 2 | ||||
| 13 | 9.51 | 0.0002 | 2058 | 5 | 0.5 | 1 | 3 | 1 | 6.3 (1.4–13.6) | 5 (100) | 3 | ||||
| 14 | 5.40 | 0.003 | 2868 | 5 | 0.9 | 2 | 2 | 1 | 7.2 (0.3–13.3) | 3 (60) | 4 | ||||
| 15 | 4.30 | 0.007 | 4944 | 5 | 1.2 | 1 | 1 | 1 | 2 | 6.1 (1.3–13.3) | 4 (80) | 2 | |||
| 16 | 3.36 | 0.002 | 12763 | 9 | 2.7 | 1 | 1 | 2 | 4 | 1 | 7.6 (0.8–15.4) | 7 (78) | 5 | ||
| 17 | 3.63 | 0.007 | 7251 | 5 | 1.7 | 4 | 1 | 6.1 (2.6–9.0) | 3 (60) | 1 | |||||
| 18 | 4.29 | 0.003 | 6120 | 5 | 1.4 | 4 | 1 | 6.1 (2.6–9.0) | 3 (60) | 1 | |||||
| 19 | 3.73 | 0.003 | 7151 | 7 | 1.9 | 1 | 3 | 3 | 7.8 (2.2–14.0) | 3 (43) | 2 | ||||
| 20 | 7.00 | 0.0009 | 2266 | 5 | 0.7 | 1 | 1 | 2 | 1 | 7.7 (3.7–10.0) | 4 (80) | 1 | |||
| 21 | 3.97 | 0.005 | 5491 | 6 | 1.5 | 1 | 2 | 1 | 1 | 1 | 8.1 (3.6–13.2) | 5 (83) | 2 | ||
| 22 | 5.31 | 0.003 | 3735 | 5 | 0.9 | 1 | 1 | 1 | 1 | 1 | 6.7 (1.3–13.6) | 2 (40) | 2 | ||
Founders are defined as individuals for whom there are no ancestral genealogical relationships in the Utah Population Database. Thus, they are the earliest generation in the database. FSIR: familial standardized incidence ratio. JIA subtypes: S = systemic JIA, R = RF + polyarticular JIA; P = RF negative polyarticular JIA, O = oligoarticular JIA, E = enthesitis related arthritis, Ps = psoriatic JIA, U = undifferentiated JIA. ANA: Anti nuclear antibody.