Table 2.
Relative class | Cases | Controls | RR (95% CI) | P value | ||||
---|---|---|---|---|---|---|---|---|
Relatives | JIA | Rate | Relatives | JIA | Rate | |||
Siblings | 544 | 14 | 0.0257 | 3578 | 8 | 0.0022 | 11.6 (4.9–27.5) | < 2.59 × 10−8 |
First cousins | 1896 | 10 | 0.0053 | 10969 | 11 | 0.0010 | 5.82 (2.5–13.8) | < 6.07 × 10−5 |
Second cousins | 6348 | 8 | 0.0012 | 36247 | 44 | 0.0012 | 1.05 (0.5–2.23) | 0.89 |
Total | 8788 | 32 | 0.0038 | 50794 | 63 | 0.0012 |
The rate of JIA among relatives of cases was compared with the rate of JIA among relatives of controls to yield the recurrence risk of JIA among relatives of probands with JIA. Significant results are shown in bold. RR = recurrence risk.