Table 2.
Publication | Treatments | PPI | Nissen | Progression PPI | Progression Nissen | Regression PPI | Regression Nissen | Study type |
Gatenby et al[6], 2009 | PPI vs Nissen | 646 | 41 | 154 (24) | 4 (10) | NA | NA | Cohort |
Parrilla et al[28], 2003 | H2RA/PPI vs Nissen | 43 | 58 | 10 (23) | 5 (9) | 2 (5) | 5 (9) | RCT |
Rossi et al[29], 2006 | PPI vs successful Nissen | 19 | 16 | NA | NA | 12 (63) | 16 (100) | Case comparison |
Total | 708 | 115 | 164 (23.8) | 9 (9.1) | 14 (22.6) | 21 (28.4) |
PPI: Proton pump inhibitor; H2RA: H2 receptor antagonist; RCT: Randomized controlled trial; NA: Not applicable.