Skip to main content
. 2010 Aug 15;21(16):2966–2974. doi: 10.1091/mbc.E10-01-0015

Figure 8.

Figure 8.

Regulation of CREB by HIPK2 in genotoxic stress. CREB is activated through phosphorylation of Serine 133 in the KID domain by PKA and related kinases in response to various receptor-mediated stimuli (Mayr and Montminy, 2001). This study demonstrated that genotoxic stress, such as etoposide, activates HIPK2, which in turn activates CREB through phosphorylation of Serine 271 adjacent to the Q2 domain and the b-zip domain of CREB. HIPK2 does not phosphorylate CREB at Serine 133. Phosphorylation of CREB at Serine 271 by HIPK2 increases CBP recruitment. CREB phosphorylation besides these two sites is discussed in the text and reviewed in Johannessen et al. (2004).