Table 2.
CFS/ME-associated genes and transcription factors in patients with CFS/ME, Q-fever-associated CFS/ME and endogenous depression
| Gene symbol | GenBank accession number | Taqman assay ID‡ | CFS/ME (n=111) | Q-CFS/ME (n=6) | Endogenous depression (n=14) | |||
| Fold difference | p Value | Fold difference | p Value | Fold difference | p Value | |||
| ABCD4* | NM_020323 | Hs00245340_m1 | 2.21 | 0.01 | 3.01 | 0.031 | 1.42 | 0.26 |
| ACTR3 | NM_005721 | Hs00828586_m1 | 13.53 | 0.0029 | 17.77 | 0.04 | 1.22 | 0.72 |
| AKAP10 | NM_007202 | Hs00183673_m1 | 5.22 | 0.01 | 6.28 | 0.031 | 1.16 | 0.38 |
| ANAPC11* | NM_016476 | Hs00212858_m1 | 2.57 | 0.006 | 1.47 | 0.002 | 1.11 | 0.37 |
| ANAPC5 | NM_016237 | Hs00212120_m1 | 2.04 | 0.002 | 1.07 | 0.045 | 1.32 | 0.392 |
| APP | NM_201413 | Hs00169098_m1 | 1.42 | 0.00003 | 0.23 | 0.001 | 1.59 | 0.021 |
| ARL4C | NM_005737 | Hs00255039_s1 | 7.15 | 0.00001 | 5.25 | 0.0023 | 1.18 | 0.76 |
| ARPC5 | NM_005717 | Hs00271722_m1 | 3.71 | 0.000008 | 4.26 | 0.0047 | 1.46 | 0.49 |
| ARSD | NM_001669 | Hs00534692_m1 | 1.62 | 0.001 | 1.65 | 0.05 | 1.07 | 0.133 |
| ATP6V1C1 | NM_001695 | Hs00184625_m1 | 2.66 | 0.0009 | 2.03 | 0.021 | 1.23 | 0.75 |
| BCOR | NM_017745 | Hs00372369_m1 | 1.90 | 0.0045 | 2.37 | 0.007 | 1.09 | 0.28 |
| BMP2K | NM_198892 | Hs00214079_m1 | 8.05 | 0.01 | 14.27 | 0.04 | 1.18 | 0.125 |
| BRMS1* | NM_015399 | Hs00363036_m1 | 3.08 | 0.0002 | 2.43 | 0.037 | 1.28 | 0.194 |
| CD2BP2* | NM_006110 | Hs00272036_m1 | 4.12 | 0.000084 | 5.15 | 0.001 | 1.44 | 0.334 |
| CD47 | NM_198793 | Hs00179953_m1 | 3.38 | 0.0007 | 2.60 | 0.002 | 1.07 | 0.125 |
| CEP350 | NM_014810 | Hs00402774_m1 | 3.85 | 0.001 | 6.49 | 0.01 | 1.36 | 0.803 |
| CITED2 | NM_006079 | Hs00366696_m1 | 5.28 | 0.000031 | 6.21 | 0.049 | 1.33 | 0.172 |
| CMTM6 | NM_017801 | Hs00215083_m1 | 3.61 | 0.014 | 6.31 | 0.046 | 1.21 | 0.405 |
| CREBBP | NM_004380 | Hs00231733_m1 | 7.02 | 0.02 | 9.82 | 0.025 | 1.61 | 0.021 |
| CRK | NM_016823 | Hs00180418_m1 | 1.98 | 0.000044 | 1.29 | 0.0003 | 1.40 | 0.683 |
| CTBP1 | NM_001328 | Hs00179922_m1 | 5.13 | 0.071 | 4.16 | 0.02 | 1.45 | 0.134 |
| CXCR4 | NM_003467 | Hs00607978_s1 | 13.46 | 0.00009 | 28.13 | 0.007 | 1.05 | 0.128 |
| EBI2 | NM_004951 | Hs00270639_s1 | 5.99 | 0.002 | 26.16 | 0.011 | 0.88 | 0.687 |
| EGR1 | NM_001955 | Hs00152928_m1 | 1.69 | 0.03 | 0.34 | 0.026 | 1.33 | 0.65 |
| EGR3 | NM_004421 | Hs00231780_m1 | 2.11 | 0.017 | – | – | – | – |
| EIF2B4* | NM_172195 | Hs00248984_m1 | 2.87 | 0.0026 | 1.13 | 0.048 | 0.58 | 0.739 |
| EIF3S10 | NM_003750 | Hs00186707_m1 | 2.10 | 0.0034 | 1.55 | 0.067 | 1.29 | 0.295 |
| EIF4G1* | NM_198241 | Hs00191933_m1 | 2.42 | 0.0007 | 0.34 | 0.035 | 1.16 | 0.165 |
| EIF4G3 | NM_003760 | Hs00186804_m1 | 2.17 | 0.00012 | 3.22 | 0.0079 | 1.35 | 0.83 |
| ETS1 | NM_005238 | Hs00901425_m1 | 30.82 | 0.0008 | 37.57 | 0.055 | 1.09 | 0.761 |
| FAM126B | NM_173822 | Hs00545158_m1 | 3.19 | 0.01 | 5.52 | 0.03 | 1.26 | 0.906 |
| FNTA | NM_002027 | Hs00357739_m1 | 3.86 | 0.0007 | 2.80 | 0.001 | 1.24 | 0.254 |
| GABARAPL1* | NM_031412 | Hs00744468_s1 | 5.27 | 0.00042 | 1.83 | 0.008 | 1.47 | 0.525 |
| GABPA | NM_002031 | Hs00745591_s1 | 15.40 | 0.0001 | 1.91 | 0.027 | 1.12 | 0.716 |
| GCN1L1 | NM_006836 | Hs00412445_m1 | 1.18 | 0.00072 | 0.70 | 0.0015 | 1.07 | 0.443 |
| GLTSCR2 | NM_015710 | Hs00414236_m1 | 5.49 | 0.0016 | 5.03 | 0.038 | 1.17 | 0.807 |
| GNAS | NM_080425 | Hs00255603_m1 | 2.37 | 0.000045 | 1.56 | 0.0021 | 1.56 | 0.004 |
| GSN* | NM_198252 | Hs00609276_m1 | 2.56 | 0.00037 | 2.40 | 0.01 | 1.11 | 0.312 |
| GTF2A2 | NM_004492 | Hs00362112_m1 | 1.08 | 0.002 | 0.52 | 0.039 | 1.13 | 0.375 |
| HIF1A | NM_001530 | Hs00153153_m1 | 0.66 | 0.019 | 2.67 | 0.012 | 1.28 | 0.255 |
| IFNAR1 | NM_000629 | Hs00265057_m1 | 3.30 | 0.00025 | 3.02 | 0.009 | 1.32 | 0.853 |
| IL10RA* | NM_001558 | Hs00387004_m1 | 1.34 | 9.87E-06 | – | – | – | – |
| IL6R | NM_000565 | Hs00794121_m1 | 2.49 | 0.06 | – | – | – | – |
| IL6ST | NM_002184 | Hs00174360_m1 | 3.34 | 0.0011 | 1.67 | 0.034 | 1.36 | 0.617 |
| IL7R | NM_002185 | Hs00233682_m1 | 0.52 | 0.032 | – | – | – | – |
| JAK1 | NM_002227 | Hs00233820_m1 | 12.73 | 0.0000008 | 15.51 | 0.04 | 1.05 | 0.623 |
| KHSRP* | NM_003685 | Hs00269352_m1 | 1.82 | 0.00026 | 0.35 | 0.0016 | 1.22 | 0.55 |
| MAPK9 | NM_139070 | Hs00177102_m1 | 1.58 | 0.045 | 1.29 | 0.05 | 0.95 | 0.213 |
| METTL3 | NM_019852 | Hs00219820_m1 | 1.30 | 0.0001 | 0.77 | 0.01 | 1.17 | 0.215 |
| MRPL23* | NM_021134 | Hs00221699_m1 | 2.62 | 0.001 | 0.80 | 0.029 | 1.36 | 0.79 |
| MRPS6 | NM_032476 | Hs00606808_m1 | 2.75 | 0.025 | 1.87 | 0.014 | 1.34 | 0.451 |
| MRRF | NM_138777 | Hs00751845_s1 | 8.23 | 0.0004 | 2.84 | 0.03 | 1.22 | 0.25 |
| MSN† | NM_002444 | Hs00792607_mH | 4.85 | 0.0016 | 7.49 | 0.002 | 1.35 | 0.962 |
| MTMR6 | NM_004685 | Hs00395064_m1 | 6.60 | 0.0025 | 4.12 | 0.048 | 1.12 | 0.15 |
| NFKB1 | NM_003998 | Hs00231653_m1 | 5.01 | 0.00027 | 5.01 | 0.001 | 1.28 | 0.41 |
| NHLH1 | NM_005589 | Hs00271582_s1 | 58.31 | 7.00E-04 | – | – | – | – |
| NR1D2 | NM_005126 | Hs00233309_m1 | 2.06 | 0.00016 | 1.56 | 0.0006 | 0.73 | 0.96 |
| NTE* | NM_006702 | Hs00198648_m1 | 2.92 | 0.001 | 7.34 | 0.02 | 1.49 | 0.579 |
| NUFIP2 | NM_020772 | Hs00325168_m1 | 2.37 | 0.001 | 2.00 | 0.046 | 1.31 | 0.929 |
| PAPOLA | NM_032632 | Hs00413685_m1 | 0.62 | 0.00021 | 0.45 | 0.001 | 1.37 | 0.672 |
| PDCD2* | NM_002598 | Hs00751277_sH | 5.38 | 0.008 | – | – | 1.62 | 0.029 |
| PDCD6 | NM_013232 | Hs00737034_m1 | 2.54 | 0.0002 | 2.19 | 0.01 | 1.69 | 0.015 |
| PEX16* | NM_004813 | Hs00191337_m1 | 3.98 | 0.0061 | 3.32 | 0.028 | 0.68 | 0.776 |
| PGM2 | NM_018290 | Hs00217619_m1 | 4.28 | 0.000001 | 3.50 | 0.0014 | 1.07 | 0.308 |
| PIK3R1 | NM_181523 | Hs00236128_m1 | 4.04 | 0.005 | 2.60 | 0.01 | 1.14 | 0.208 |
| PKN1* | NM_213560 | Hs00177028_m1 | 4.58 | 0.0003 | 3.95 | 0.01 | 1.03 | 0.887 |
| POLR2G* | NM_002696 | Hs00275738_m1 | 2.71 | 0.001 | 1.00 | 0.039 | 0.77 | 0.916 |
| PPP2R5C | NM_002719 | Hs00604902_m1 | 4.65 | 0.013 | 8.21 | 0.045 | 1.30 | 0.906 |
| PRKAA1 | NM_006251 | Hs01562315_m1 | 4.19 | 0.0002 | 2.18 | 0.001 | 1.29 | 0.56 |
| PRKAR1A | NM_002734 | Hs00267597_m1 | 3.55 | 0.0000004 | 2.31 | 0.0001 | 1.23 | 0.83 |
| PUM2 | NM_015317 | Hs00209677_m1 | 2.73 | 0.00078 | 2.33 | 0.002 | 1.35 | 0.82 |
| RAP2C | NM_021183 | Hs00221801_m1 | 6.74 | 0.013 | 4.37 | 0.043 | 1.46 | 0.69 |
| REPIN1 | NM_013400 | Hs00274221_s1 | 4.51 | 0.00001 | 2.13 | 0.01 | 1.26 | 0.41 |
| RNF141 | NM_16422 | Hs00212656_m1 | 6.49 | 0.00000079 | 7.44 | 0.0003 | 1.19 | 0.411 |
| SELENBP1 | NM_003944 | Hs00187625_m1 | 10.57 | 0.001 | 7.00 | 0.02 | 1.06 | 0.104 |
| SFXN1 | NM_022754 | Hs00224259_m1 | 1.69 | 0.041 | 0.69 | 0.037 | 1.00 | 0.24 |
| SHPRH | NM_173082 | Hs00542737_m1 | 0.56 | 0.02 | 0.69 | 0.03 | 1.00 | 0.303 |
| SNAP23 | NM_003825 | Hs00187075_m1 | 7.00 | 0.0006 | 3.17 | 0.01 | 1.10 | 0.132 |
| SORL1 | NM_003105 | Hs00268342_m1 | 1.67 | 4.10E-08 | – | – | – | – |
| SOS1 | NM_005633 | Hs00362308_m1 | 1.02 | 0.001 | 1.02 | 0.037 | 1.27 | 0.52 |
| TAF11 | NM_005643 | Hs00194573_m1 | 1.17 | 0.001 | 0.00 | 0.02 | 1.40 | 0.57 |
| TCF3 | NM_003200 | Hs00413032_m1 | 2.40 | 0.03 | 1.63 | 0.068 | 1.29 | 0.86 |
| TDP1 | NM_018319 | Hs00217832_m1 | 3.12 | 0.001 | 3.16 | 0.01 | 1.12 | 0.83 |
| TNFRSF1A | NM_001065 | Hs00533560_m1 | 12.37 | 0.004 | 18.52 | 0.03 | 0.86 | 0.279 |
| UBTF | NM_014233 | Hs00610729_g1 | 6.38 | 0.002 | 2.40 | 0.011 | 1.09 | 0.297 |
| USP38 | NM_032557 | Hs00261419_m1 | 3.35 | 0.01 | 4.98 | 0.078 | 1.43 | 0.367 |
| WAPAL | NM_015045 | Hs00386162_m1 | 3.94 | 0.003 | 3.69 | 0.026 | 1.17 | 0.44 |
| WDR26 | NM_025160 | Hs00228535_m1 | 1.36 | 0.0008 | 0.71 | 0.01 | 1.48 | 0.95 |