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. 2010 Aug 13;5(8):e12174. doi: 10.1371/journal.pone.0012174

Figure 2. LAIR-2/Fc inhibits collagen but not TRAP-induced platelet aggregation.

Figure 2

Aggregation of platelet rich plasma (PRP) in response to collagen was measured using an optical aggregometer. Panel A: Platelet aggregation in response to 50 µM TRAP alone (PBS) or in the presence of 100 µg/ml LAIR-1/Fc, LAIR-2/Fc or SIRL-1/Fc. Panel B: Platelet aggregation in response to collagen (1 µg/ml) alone (PBS) or in the presence of 100 µg/ml LAIR-1/F, LAIR-2/Fc or SIRL-1/Fc. Panel C: Platelet aggregation in response to collagen (1 µg/ml) alone (PBS) or in the presence of 0.01 µg/ml, 0.1 µg/ml or 1.0 µg/ml LAIR-2/Fc. Panel D: Platelet aggregation in response to 0.5 µg/ml, 1 µg/ml, 2 µg/ml or 4 µg/ml collagen in the presence of 1.0 µg/ml LAIR-2/Fc.